Actor and comedian Gilbert Gottfried, perhaps best known for his iconic, over-the-top voice, has died aged 67, his family has confirmed.

“We are heartbroken to announce the passing of our beloved Gilbert Gottfried after a long illness,” they said in a statement. “Besides being the most iconic voice in comedy, Gilbert was a wonderful husband, brother, friend and father to his two young children. Although today is a sad day for all of us, keep laughing too as much as possible in honor of Gilbert Love, the Gottfried family.

By Weekly entertainment, Gottfried died of complications from recurrent ventricular tachycardia, caused by a rare condition called myotonic dystrophy type II. According to the Genetic and Rare Diseases Information Clearinghouse, it can lead to abnormal heart rhythms by affecting a person’s muscles.

Among those who expressed their condolences on Tuesday was Seinfeld starring Jason Alexander. “Gilbert Gottfried made me laugh at times when laughter didn’t come easily,” he tweeted. “What a gift. I didn’t know him well but I loved what he shared with me. My best wishes and sympathy to his family.”

Apart from his stand-up work, Gottfried was also known for his acting career. Some of his most famous voice roles include the parrot Iago in Aladdinand Krang in the 2014 series Teenage Mutant Ninja Turtles. Additionally, he voiced Aflac’s duck mascot until 2011. He was also briefly a Saturday Night Live actor during its sixth season, and appeared in films like Beverly Hills Cop II and Problem child.